Recommendations for the classification of germline variants in ...

Exonucleases are enzymes that work by cleaving nucleotides one at a time from the end (exo) of a polynucleotide chain. A hydrolyzing reaction that breaks ...

This entry represents the domain that is responsible for the 3'-5' exonuclease proofreading activity of Escherichia coli DNA polymerase I (polI) and other ...

由 DN Church 著作 · 2013 · 被引用 392 次 — We have demonstrated that somatic POLE exonuclease domain mutations occur in ∼7% of sporadic ECs and are associated with a MSI-negative ...

由 L Betancurt-Anzola 著作 · 2023 · 被引用 1 次 — Replicative DNA polymerases duplicate entire genomes at high fidelity. This feature is shared among the three domains of life and is ...

由 S Dong 著作 · 2022 · 被引用 6 次 — Abstract. Inactivating mutations in the exonuclease domain of POLE induce somatic hypermutation resulting in a high tumor mutation burden (TMB) ...

由 DN Church 著作 · 2013 · 被引用 392 次 — We have demonstrated that somatic POLE exonuclease domain mutations occur in ∼7% of sporadic ECs and are associated with a MSI-negative hypermutator phenotype ...

由 S Tabor 著作 · 1987 · 被引用 81 次 — The exonuclease activities can be inactivated selectively by an oxidation reaction that requires molecular oxygen, a reducing agent, and iron at a concentration ...

由 W Tian 著作 · 2022 · 被引用 9 次 — Objective: This study was aimed to profile hotspot exonuclease domain mutations (EDMs) of the DNA polymerase ϵ gene (POLE) in endometrial ...

由 P Mur 著作 · 2023 · 被引用 1 次 — Results. Gene-specific variant classification recommendations for non-disruptive variants located in the exonuclease domain of POLE and POLD1 ...

AbstractPOLE driver mutations in the exonuclease domain (ExoD driver) are prevalent in several cancers, including colorectal cancer and endometrial.